Iowa Sleep Blog

New Medication

Friday, May 24, 2013

Federal advisory panel on Wednesday endorsed  Suvorexant (Merck product). FDA may approve by this fall.  


belongs to a new class to insomnia agents which block orexin. Orexin is a excitatory neurotransmitter.    This would be the first in a new class and it works in a different manner than currently available drugs for insomnia.  

Before this we had agents that: 1)  increased GABA effect (benzos and nonbenzos),2)  agents that blocked the histamine (Silenor), and 3)  agents that worked on the SCN nucleus (Ramelteon).
-Dr Zorn

Thank you Dr Zorn/dkm